Proapoptotic protein Siva binds to the muscle protein telethonin in cardiomyocytes during coxsackieviral infection

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Proapoptotic protein Siva binds to the muscle protein telethonin in cardiomyocytes during coxsackieviral infection.

AIMS Coxsackievirus B3 (CVB3) is known to cause a variety of human diseases including acute and chronic myocarditis as well as dilated cardiomyopathy (DCM). However, the mechanisms by which CVB3 causes diseases are not well understood. METHODS AND RESULTS Studies identifying protein-protein interactions during CVB3 infection are useful in delineating the pathogenesis of acute or chronic myoca...

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Pyrin, product of the MEFV locus, interacts with the proapoptotic protein, Siva.

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Telethonin protein expression in neuromuscular disorders.

Telethonin is a 19-kDa sarcomeric protein, localized to the Z-disc of skeletal and cardiac muscles. Mutations in the telethonin gene cause limb-girdle muscular dystrophy type 2G (LGMD2G). We investigated the sarcomeric integrity of muscle fibers in LGMD2G patients, through double immunofluorescence analysis for telethonin with three sarcomeric proteins: titin, alpha-actinin-2, and myotilin and ...

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ژورنال

عنوان ژورنال: Cardiovascular Research

سال: 2008

ISSN: 0008-6363

DOI: 10.1093/cvr/cvn276